Malaysian men have used Eurycoma longifolia for hundreds of years to enhance the quantity and quality of their sexual engagements.*
Malaysian Eurycoma longifolia (100:1 extract) stimulates the production of luteinizing hormone, which signals the testes to produce testosterone. Eurycoma blocks testosterone from converting to estrogen and boosts libido. It also controls the conversion of DHEA to testosterone, further increasing testosterone and lowering estrogen.
One study found that daily doses of Eurycoma increase total and free testosterone by 14% and 34%, respectively. Eurycoma also inhibits ROCK2, leading to greater blood flow to the genitals and stronger erections.*
- Boosts natural testosterone*
- Stimulates luteinizing hormone (LH) production*
- Prevents testosterone and DHEA from converting to estrogen*
- Increases blood flow to the penis*
Eurycoma longifolia, aka Tongkat Ali, is a Malaysian herb used by Malaysian men for thousands of years to enhance both the quantity and quality of their sexual experiences.
Four Powerful Pro-Testosterone and Pro-Sexual Actions
Eurycoma increases testosterone and produces its sexual effects through four biochemical mechanisms:
- Eurycoma increases testosterone by indirectly stimulating the testes (through LH and FSH) to increase testosterone.
- Eurycoma increases testosterone by blocking the conversion of testosterone to estradiol.
- Eurycoma increases testosterone by controlling the conversation DHEA to testosterone.
- Eurycoma produces bigger and stronger erections by inhibiting ROCK-2 (rho kinase 2).
Eurycoma Builds Muscle
Increasing testosterone should also increase muscle mass, assuming it occurs with proper exercise and adequate nutrition.
One study of men between the ages of 57 and 72 who took Eurycoma for 5 weeks increased free and total testosterone with a measurable increase of "muscular force."
Another study involved 14 men on an intense strength-training program while taking Eurycoma. The men increased arm circumference significantly compared to the placebo group (6.8% to 2.8%).
- Ezzat SM et al. Rho-Kinase II Inhibitory Potential of Eurycoma longifolia New Isolate for the Management of Erectile Dysfunction. Evidence Based Complementary and Alternative Medicine, 15 May 2019. Background: Eurycoma longifolia Jack (Fam.: Simaroubaceae), known as Tongkat Ali (TA), has been known as a symbol of virility and sexual power. The aim of the study was to screen E. longifolia aqueous extract (AE) and isolates for ROCK-II inhibition. Results: The AE (1-10 μg/ml) showed a significant inhibition for ROCK-II activity (62.8-81%) at P < 0.001 with an IC50 (651.1 ± 32.9 ng/ml) compared to Y-27632 ([(+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride]) (68.15-89.9 %) at same concentrations with an IC50 (192 ± 8.37 ng/ml). Chromatographic purification of the aqueous extract (AE) allowed the isolation of eight compounds; stigmasterol T1, trans-coniferyl aldehyde T2, scopoletin T3, eurycomalactone T4, 6α- hydroxyeurycomalactone T5, eurycomanone T6, eurycomanol T7, and eurycomanol-2-O-β-D-glucopyranoside T8. This is the first report for the isolation of T1 and T3 from E. longifolia and for the isolation of T2 from genus Eurycoma. The isolates (at 10 μg/ml) exhibited maximum inhibition % of ROCK-II 82.1 ± 0.63 (T2), 78.3 ± 0.38 (T6), 77.1 ± 0.11 (T3), 76.2 ± 3.53 (T4), 74.5 ± 1.27 (T5), 74.1 ± 2.97 (T7), 71.4 ± 2.54 (T8), and 60.3 ± 0.14 (T1), where the newly isolated compound trans-coniferyl aldehyde T2 showed the highest inhibitory activity among the tested isolated compounds and even higher than the total extract AE. The standard Y-27632 (10 μg/ml) showed 89.9 ± 0.42 % inhibition for ROCK-II activity when compared to control at P < 0.0001. Conclusion: The traditional use of E. longifolia as aphrodisiac and for male sexual disorders might be in part due to the ROCK-II inhibitory potential.
- Low BS et al. Standardized quassinoid-rich Eurycoma longifolia extract improved spermatogenesis and fertility in male rats via the hypothalamic-pituitary-gonadal axis. J Ethnopharmacol. 2013 Feb 13;145(3):706-14. Ethnopharmacological Relevance: Eurycoma longifolia Jack, a small Simaroubaceae tree, known locally as 'Tongkat Ali' is popularly used as a sexual tonic in traditional medicine for aphrodisiac activity and improvement of fertility and male libido. Aim of the Study: To investigate the effects of the standardized bioactive fraction of E. longifolia and its chemical constituents on the male fertility and the mechanisms of action involved. Material and Methods: The powdered roots of E. longifolia were extracted separately with methanol and water. The organic extract upon further fractionation on HP 20 resin and elution with the methanol/water mixture afforded four fractions (F1-F4). These fractions, together with the crude aqueous (W) and organic extracts were standardized following their respective major quassinoid content and profile. The effects of the fractions on the rat spermatogenesis were compared with that of the aqueous extract (W) to determine the bioactive fraction. The effects of the bioactive fraction on the sperm count and quality, the histological morphometric changes on the spermatogenesis cycle, fertility and hormonal changes of plasma testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH) and estrogen in the animals upon oral administration were determined. The effects of the bioactive quassinoids on the testosterone release from the isolated testicular interstitial cells rich in Leydig cells, were also described. Results: The male rats orally administered with 25mg/kg of F2 and 250mg/kg of W, significantly increased the sperm concentration when compared with that of the control animals (P < 0.05). High performance liquid chromatography analysis revealed that 25mg/kg of F2 and 250mg/kg of W were almost similar in concentration of eurycomanone, the major and most potent quassinoid. Microscopic morphometrical analysis of the rat testis following treatment with F2, showed significant increase in the number of spermatocytes and round spermatids at Stage VII of the spermatogenesis cycle when compared to that of the control (P < 0.05). The estimated spermatozoa production rate and the number of Leydig cells were also elevated (P < 0.001). The fertility index, fecundity index and the pup litter size delivered from the females after mating with the males treated with F2 were increased. The plasma testosterone level of the animals given 25mg/kg of F2 orally was significantly different at day-26 (P < 0.05) and day-52 (P < 0.01) from those of control but was not different at day-104. The testicular testosterone also peaked in the animals treated with 25mg/kg F2 and was higher than that in the plasma. The plasma LH and FSH levels of the rats treated with 25mg/kg of F2 were higher than those of the control (P < 0.001). In contrast, the plasma estrogen level was significantly lower than that of the untreated control. Amongst the isolated quassinoids of F2, eurycomanone and 13α(21)-dihydroeurycomaone significantly increased the testosterone level from the Leydig cells of the testicular interstitial cells cultured in vitro (P < 0.05). Conclusion: The standardised extract F2 of E. longifolia and its major quassinoids especially eurycomanone improved the rat spermatogenesis by affecting the hypothalamic-pituitary-gonadal axis and the potential efficacy may be worthy of further investigation.
- Muhamad AS et al. Eurycoma longifolia Jack: Medicinal properties and its effects on endurance exercise performance. Asian Journal of Exercise & Sport Science, 2009, Vol. 6 (No. 1). ABSTRACT: This review article discusses the medicinal properties of a herbal plant, Eurycoma longifolia Jack, and its possible ergogenic effect on endurance exercise performance. To date, herbs or plant products that have been investigated as ergogenic aids for enhancing endurance performance are caffeine, ginseng, mahuang, ephedrine and related alkaloids. Eurycoma longifolia Jack is one of the herbs found in Malaysia. It is commonly known as ‘Tongkat Ali’ in Malaysia and as ‘Pasak Bumi’ in Indonesia. It is also referred to as ‘Malaysian ginseng’ since it is well-known among various ethnic groups in Malaysia for treating various diseases and enhancing health. Eurycoma longifolia Jack is a tall, slender shrubby tree found on sandy soil. It belongs to the Simaroubaceae family and grows wildly in Southeast Asian countries, i.e. Malaysia, Indonesia, Thailand, and Myanmar. To our knowledge, studies on Eurycoma longifolia Jack as an ergogenic aid for enhancing endurance performance is lacking. Thus, this review article highlights the available studies on its purported medicinal properties as well as studies that have been carried out to investigate its effects on physiological responses and endurance exercise performance.
- Rehman SU et al. Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology. Molecules, 2016, 21(3), 331. ABSTRACT: Eurycoma longifolia Jack (known as tongkat ali), a popular traditional herbal medicine, is a flowering plant of the family Simaroubaceae, native to Indonesia, Malaysia, Vietnam and also Cambodia, Myanmar, Laos and Thailand. E. longifolia, is one of the well-known folk medicines for aphrodisiac effects as well as intermittent fever (malaria) in Asia. Decoctions of E. longifolia leaves are used for washing itches, while its fruits are used in curing dysentery. Its bark is mostly used as a vermifuge, while the taproots are used to treat high blood pressure, and the root bark is used for the treatment of diarrhea and fever. Mostly, the roots extract of E. longifolia are used as folk medicine for sexual dysfunction, aging, malaria, cancer, diabetes, anxiety, aches, constipation, exercise recovery, fever, increased energy, increased strength, leukemia, osteoporosis, stress, syphilis and glandular swelling. The roots are also used as an aphrodisiac, antibiotic, appetite stimulant and health supplement. The plant is reported to be rich in various classes of bioactive compounds such as quassinoids, canthin-6-one alkaloids, β-carboline alkaloids, triterpene tirucallane type, squalene derivatives and biphenyl neolignan, eurycolactone, laurycolactone, and eurycomalactone, and bioactive steroids. Among these phytoconstituents, quassinoids account for a major portion of the E. longifolia root phytochemicals. An acute toxicity study has found that the oral Lethal Dose 50 (LD50) of the alcoholic extract of E. longifolia in mice is between 1500-2000 mg/kg, while the oral LD50 of the aqueous extract form is more than 3000 mg/kg. Liver and renal function tests showed no adverse changes at normal daily dose and chronic use of E. longifolia. Based on established literature on health benefits of E. longifolia, it is important to focus attention on its more active constituents and the constituents' identification, determination, further development and most importantly, the standardization. Besides the available data, more evidence is required regarding its therapeutic efficacy and safety, so it can be considered a rich herbal source of new drug candidates. It is very important to conserve this valuable medicinal plant for the health benefit of future generations.
- Solomon MC et al. In vivo effects of Eurycoma longifolia Jack (Tongkat Ali) extract on reproductive functions in the rat. Andrologia. 2014 May;46(4):339-48. ABSTRACT: An aqueous extract of Eurycoma longifolia (Tongkat Ali; TA) roots is traditionally used to enhance male sexuality. Because previous studies are limited to only few sperm parameters or testosterone concentration, this study investigated the in vivo effects of TA on body and organ weight as well as functional sperm parameters in terms of safety and efficacy in the management of male infertility. Forty-two male rats were divided into a control, low-dose (200 mg kg(-1) BW) and high-dose (800 mg kg(-1) BW) group (n = 14). Rats were force-fed for 14 days and then sacrificed. Total body and organ weights of the prostate, testes, epididymides, gastrocnemius muscle and the omentum were recorded. Moreover, testosterone concentration, sperm concentration, motility, velocity, vitality, acrosome reaction and mitochondrial membrane potential (MMP) were assessed. Whilst TA decreased BW by 5.7% (P = 0.0276) and omentum fat by 31.9% (P = 0.0496), no changes in organ weights were found for the prostate, testes and epididymides. Testosterone concentration increased by 30.2% (P = 0.0544). Muscle weight also increased, yet not significantly. Whilst sperm concentration, total and progressive motility and vitality increased significantly, MMP improved markedly (P = 0.0765) by 25.1%. Because no detrimental effect could be observed, TA appears safe for possible treatment of male infertility and ageing male problems.