PhGABA is an orally bioavailable form of the inhibitory neurotransmitter GABA that relieves stress and induces sleep.*

PhGABA is a bioavailable form of the inhibitory neurotransmitter GABA. When stressed, our brains experience an uninterrupted flow of stimulatory neurotransmitters, causing restlessness and irritability.* GABA and phGABA inhibit the flow of these stimulatory neurotransmitters, calming the brain and body. PhGABA also causes the release of GABA for a one-two sleep-inducing punch.*

Double-blind studies find phGABA increases intellectual capacity, increases physical strength, and reduces fatigue in stressed individuals. It increases work capacity in humans and the performance of animals during swim tests. PhGABA also has cardioprotective properties. The plasma half-life of PhGABA (250 mg) is 5.3 hours, with most of it excreted unchanged.*

  • Induces restfulness*
  • Promotes sense of calm*
  • Reduces fatigue during stress*
  • Increases intellectual capacity*
  • Improves physical strength*
  • Promotes cardiovascular health*


PhGABA (beta-phenyl-gamma-aminobutyric acid) is a psychotropic (any substance capable of affecting the mind, emotions, or behavior) compound first developed by Russian scientists in the 1960s.

The Russian Aviation and Space Agency included PhGABA in the medical kits used by cosmonauts on space flights. The scientists liked the compound because smaller doses enhance cognition while offering a sense of calmness, whereas slightly larger doses induce sleep.

Double-blind studies confirm that PhGABA is a nootropic compound, increasing cognition while reducing fatigue.

How Does PhGABA Work?

When stressed, the brain gets flooded with stimulatory neurotransmitters, causing restlessness and irritability. When things go right, a naturally produced inhibitory neurotransmitter known as GABA (gamma-aminobutyric acid) interferes, allowing the body to relax.

PhGABA, however, is a derivative of GABA. It not only acts like GABA but also causes the body to release more GABA, thereby providing a two-fisted attack on anxiety and sleeplessness in sufficient doses.

  1. Lapin I. Phenibut: a tranquilizer and nootropic drug. CNS Drug Rev. 2001 Winter;7(4):471-81.
  2. Blackshaw LA. Receptors and transmission in the brain-gut axis: potential for novel therapies. IV. GABA(B) receptors in the brain-esophageal axis. Am J Physiol Gastrointest Liver Physiol. 2001 Aug;281(2):G311-5.
  3. Lapin IP. Differences and similarity in the interaction of fenibut, baclofen, and diazepam with phenylethylamine. Farmakol Toksikol. 1985 Jul-Aug;48(4).
  4. Shulgina GI. On neurotransmitter mechanisms of reinforcement and internal inhibition. Pavlov J Biol Sci. Oct-Dec 1986;21(4):129-40. doi: 10.1007/BF02734511.

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.