Resveratrol

What Is Resveratrol?

Resveratrol is a potent longevity polyphenol, commonly found in red wine and cocoa, that combats inflammation, protects cells, supports cardiovascular health, and manages estrogen.*

Benefits of Resveratrol

• Combats inflammation*
• Protects cells*
• Supports cardiovascular health*
• Boosts testosterone*
• Controls estrogen.*
• Protects the liver*
• Manages glucose and insulin*
• Supports brain health*
• Builds muscle*
• Increase strength*

What You Need to Know About Resveratrol

Resveratrol is a polyphenol first isolated in 1939 from the roots of white hellebore and later in grapes, berries, cocoa, peanuts, plums, and others. Resveratrol is also a potent longevity agent that combats inflammation, protects cells, supports cardiovascular health, boosts testosterone, and manages estrogen.*

Resveratrol is a decades-heralded longevity agent. The association between resveratrol and cardiovascular health ushered in decades of intensive research. Singh et al. found an incredible 244 completed resveratrol trials.

Singh et al. regard resveratrol as "pleiotropic," meaning it can address the gene dysregulations in various areas. Resveratrol modulates many cell signaling pathways, positively affecting numerous health concerns from multiple angles.

Resveratrol for Health

Resveratrol provides multiple health benefits:

1. Glucose and Insulin Management: Resveratrol decreases blood glucose levels and hemoglobin A1C and improves insulin sensitivity. At 150 mg daily, resveratrol reduces the size of adipocytes. At 1500 mg daily, resveratrol reduces body mass index, waist circumference, and total insulin secretion.
2. Inflammation Health: Resveratrol supports healthy inflammation responses in cardiovascular tissue and the gastrointestinal tract.
3. Liver Health: At 600 mg daily for 3 months, resveratrol reduces glucose, insulin resistance, cholesterol, and liver enzymes ALT and AST.
4. Health Brain Support: Resveratrol supports mitochondrial associated with cognition. It also enhances cerebrovascular responsiveness.
5. Cardiovascular Support: Research shows resveratrol has multi-targeting cardio-protective properties.

Resveratrol for Athletes and Lifters

Resveratrol is a performance-enhancing supplement:

1. Boosts Testosterone: Resveratrol boosts testosterone in animals by 51.6%.
2. Controls Estrogen: Resveratrol is a potent aromatase inhibitor, decreasing the conversion of testosterone to estrogen and increasing testosterone.
3. Builds Muscle and Strength: Resveratrol makes muscle fibers grow larger and stronger. Montesanto et al. (2013) find resveratrol induces young muscle cells (myoblasts) to develop and stimulate muscle-protein synthesis. Resveratrol signals IGF-1, activating proteins and inducing hypertrophy in skeletal muscle.

Any Side Effects?

Another great thing about resveratrol is its lack of effects at 600-1200 mg daily. Mega doses of 2.5 to 5.0 grams might cause abdominal discomfort, but that's a higher dose than any human would probably ever need.

People on blood thinners should consult their doctor before taking resveratrol, as the compound has anti-platelet effects similar to fish oil.

Singh et al. note: "The side effects of resveratrol are mild and sporadic compared to its overwhelming health benefits."

Research on Resveratrol

1. Juan ME et al. Trans-Resveratrol, a natural antioxidant from grapes, Increases sperm output in healthy rats. J Nutr. 2005 Apr;135(4):757-60.
2. Bhat KP et al. Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. Cancer Res. 2001 Oct 15;61(20):7456-63.
3. Henry LA et al. Resveratrol: phytoestrogen effects on reproductive physiology and behavior in female rats. Horm Behav. 2002 Mar;41(2):220-8.
4. Matsumura A et al. Comparative study of oestrogenic properties of eight phytoestrogens in MCF7 human breast cancer cells. J Steroid Biochem Mol Biol. 2005 Apr;94(5):431-43.
5. Bowers JL et al. Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta. Endocrinology. 2000 Oct;141(10):3657-67.
6. Lu R et al. Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells. J Cell Physiol. 1999 Jun;179(3):297-304.
7. Turner RT et al. Is resveratrol an estrogen agonist in growing rats? Endocrinology. 1999 Jan;140(1):50-4.
8. Bhat KP et al. Resveratrol exhibits cytostatic and antiestrogenic properties with human endometrial adenocarcinoma (Ishikawa) cells. Cancer Res. 2001 Aug 15;61(16):6137-44.
9. Wang Y et al. The Red Wine Polyphenol Resveratrol Displays BI-Level Inhibition on Aromatase in Breast Cancer Cells. Toxicol Sci. 2006 Apr 11
10. Wallerath T et al. A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase. Nitric Oxide. 2005 Mar;12(2):97-104.
11. Lekakis J et al. Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. Eur J Cardiovasc Prev Rehabil. 2005 Dec;12(6):596-600.
12. Buluc M et al. Resveratrol decreases calcium sensitivity of vascular smooth muscle and enhances cytosolic calcium increase in endothelium. Vascul Pharmacol. 2006 Apr;44(4):231-7.
13. Labinskyy N et al. Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen. Curr Med Chem. 2006;13(9):989-96.
14. Bhat KPL et al. Biological effects of resveratrol. Antioxid Redox Signal. 2001 Dec;3(6):1041-64.
15. Bradamante S, et al. Cardiovascular protective effects of resveratrol. Cardiovasc Drug Rev. 2004 Fall;22(3):169-88.
16. de la Lastra CA et al. Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol Nutr Food Res. 2005 May;49(5):405-30. doi: 10.1002/mnfr.200500022.
17. Delmas D et al. Resveratrol: preventing properties against vascular alterations and ageing. Mol Nutr Food Res. 2005 May;49(5):377-95.
18. Valenzano DR et al. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol. 2006 Feb 7;16(3):296-300.
19. Marambaud P et al. Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides. J. Biol. Chem 2005 Nov;280(45): 37377-37382
20. Molnar V et al. Plant-derived anti-inflammatory compounds affect MIF tautomerase activity. Int Immunopharmacol. 2005 May;5(5):849-56.
21. Elmali N et al. Effect of resveratrol in experimental osteoarthritis in rabbits. Inflamm Res. 2005 Apr;54(4):158-62.
22. Kopp P. Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'? Eur J Endocrinol. 1998 Jun;138(6):619-20.
23. Constant J. Alcohol, ischemic heart disease, and the French paradox. Coron. Artery Dis. 1997; 8:645 – 649.
24. Das D K et al. Cardioprotection of red wine: role of polyphenolic antioxidants. Drugs Exp Clin Res. 1999;25(2-3):115-20.
25. Soleas GJ, Diamandis EP, Goldberg DM. The world of resveratrol. Adv Exp Med Biol. 2001;492:159-82.
26. Wyke SM, Tisdale MJ. Induction of protein degradation in skeletal muscle by a phorbol ester involves upregulation of the ubiquitin-proteasome proteolytic pathway. 2006 May;78(25):2898-2910
27. Tisdale MJ. The ubiquitin-proteasome pathway as a therapeutic target for muscle wasting. J Support Oncol. 2005 May-Jun;3(3):209-17.
28. Wyke SM et al. Induction of proteasome expression in skeletal muscle is attenuated by inhibitors of NF-kappaB activation. Br J Cancer. 2004 Nov 1;91(9):1742-50.
29. Borra MT et al. Mechanism of human SIRT1 activation by resveratrol. J Biol Chem. 2005 Apr 29;280(17):17187-95.
30. Picard F, et al. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature. 2004 Jun 17;429(6993):771-6.
31. Wolf G. Calorie restriction increases life span: a molecular mechanism. Nutr Rev. 2006 Feb;64(2 Pt 1):89-92.
32. Ingram DK et al. Calorie restriction mimetics: an emerging research field. Aging Cell. 2006 Apr;5(2):97-108.
33. Roth GS et al. Caloric restriction mimetics: the next phase. Ann N Y Acad Sci. 2005 Dec;1057:365-71.
34. Tian WX. Inhibition of fatty acid synthase by polyphenols. Curr Med Chem. 2006;13(8):967-77.
35. Kasdallah-Grissa A, et al. Protective effect of resveratrol on ethanol-induced lipid peroxidation in rats. Alcohol Alcohol. 2006 May-Jun;41(3):236-9
36. Sener G et al. Protective effects of resveratrol against acetaminophen-induced toxicity in mice. Hepatol Res. 2006 Apr 1; E-Published Ahead of Print
37. Docherty JJ et al. Effect of resveratrol on herpes simplex virus vaginal infection in the mouse. Antiviral Res. 2005 Sep;67(3):155-62.
38. Jung HJ et al. Fungicidal effect of resveratrol on human infectious fungi. Arch Pharm Res. 2005 May;28(5):557-60.
39. Palamara AT et al. Inhibition of influenza A virus replication by resveratrol. J Infect Dis. 2005 May 15;191(10):1719-29.
40. Yoo KM et al. Potent Inhibitory Effects of Resveratrol Derivatives on Progression of Prostate Cancer Cells. Arch Pharm (Weinheim). 2006 Apr 18;339(5):238-241
41. Jones SB et al. Resveratrol-induced gene expression profiles in human prostate cancer cells. Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):596-604.
42. Scifo C et al. Resveratrol and propolis as necrosis or apoptosis inducers in human prostate carcinoma cells. Oncol Res. 2004;14(9):415-26.
43. Kim YA et al. Antiproliferative effect of resveratrol in human prostate carcinoma cells. J Med Food. 2003 Winter;6(4):273-80.
44. Stewart JR et al. Resveratrol: a candidate nutritional substance for prostate cancer prevention. J Nutr. 2003 Jul;133(7 Suppl):2440S-2443S.
45. Ratan HL et al. Resveratrol – a prostate cancer chemopreventive agent? Urol Oncol. 2002 Nov-Dec;7(6):223-7.
46. Aggarwal BB, et al. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 2004 Sep-Oct;24(5A):2783-840.
47. Aziz MH et al. Cancer chemoprevention by resveratrol: in vitro and in vivo studies and the underlying mechanisms (review). Int J Oncol. 2003 Jul;23(1):17-28.
48. Delmas D et al. Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer. Curr Drug Targets. 2006 Apr;7(4):423-42.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.