Only Elite Supplements for Elite Athletes
Resveratrol is a natural polyphenol found in small amounts in red grapes and wine. Studies show resveratrol is a highly effective estrogen blocker and a potent aromatase inhibitor, minimizing negative estrogen effects and maximizing natural testosterone. Resveratrol also provides significant cardiovascular and neurological health benefits and activates fat burning. Two Rez-V™ softgels contain 600 mg of active pure trans-resveratrol, the type and amount required for an effective dose of this powerful science-backed ingredient.*
Controls Estrogen in 2 Ways*
- Controls estrogen in two ways*
- Acts as a potent estrogen blocker*
- Acts as a potent aromatase inhibitor*
- Increases natural testosterone levels*
- Protects against man-made environmental estrogens that lower testosterone*
- Stimulates fat burning*
- Promotes cardiovascular health*
- Exhibits prostate protectant effects, liver protective effects, and anti-aging effects*
Control Estrogen to Live Better and Look Better*
Active men want naturally high testosterone. "High-normal" testosterone gives you an advantage in building and maintaining a lean, muscular, hi-performance body – and it generally makes you feel great.
The trouble is, some testosterone naturally converts into estrogen through aromatization. And with elevated estrogen, you can easily gain fat, bloat with excess water, have a tough time even maintaining muscle mass and strength, and even impact your prostate health. Too much estrogen also signals the body, though negative feedback, to produce less testosterone.
While men need some estrogen to maintain cardiovascular health, it can cause many problems if it gets out of control.
Man-Made Estrogens Are Everywhere
Adding to the estrogen problem, many chemicals in the environment mimic estrogen. They're called xenoestrogens, and they're everywhere: in plastic bottles and bowls, shampoos, detergents, even toothpaste. Xenoestrogens are unavoidable and will find their way into your body every day.
Resveratrol: Estrogen Blocker
Resveratrol acts as a potent estrogen antagonist (blocker) while also acting as a "healthy" (weak) agonist in cardiovascular tissues (similar to the drugs clomiphene and tamoxifen). As a blocker, resveratrol occupies estrogen receptor sites, or biological "parking lots," so xenoestrogens can't "park" and activate the receptor – no activation means no negative effects.
Resveratrol: Aromatase Inhibitor
In higher concentrations, resveratrol also acts as an aromatase inhibitor, preventing the body from converting testosterone into estrogen, with the bonus of increasing testosterone. Resveratrol inhibits aromatase by reducing its expression and by binding to it. And, unlike pharmaceutical aromatase inhibitors, resveratrol doesn't decrease blood vessel function; it seems to improve it.*
Resveratrol: Fat Burner
Calorie deprivation activates a protein called SIRT1, which inhibits PPAR-gamma activity and causes your body to burn fat. Resveratrol activates this very same SIRT1 protein without you needing to diet excessively.*
Resveratrol: Supplement for Heath
Additionally, there's overwhelming scientific evidence that resveratrol provides potent cardiovascular benefits, anti-aging effects, and positive neurological effects. Many of these benefits stem from anti-oxidative and anti-inflammatory actions and gene modulation.*
Resveratrol is a potent longevity polyphenol, commonly found in red wine and cocoa, that combats inflammation, protects cells, supports cardiovascular health, and manages estrogen.* Learn More
Amount Per Serving % Daily Value
Other Ingredients: MCT oil (medium chain triglycerides), gelatin (bovine), glycerin (palm oil), purified water, yellow beeswax, annatto extract, sunflower lecithin.
Rez-V™ contains the purest active resveratrol available. Due to its rapid and extensive metabolism, it's best to take one large dose of resveratrol per day instead of several smaller doses.* A two-softgel dose of Rez-V contains 600 mg of pure resveratrol, the amount you need for the maximal effects.*
- Take two softgels once per day with or without food.
Can't I just drink wine to get resveratrol?
While you often hear about wine's health benefits, usually because of its resveratrol content, the best red wine only contains one mg of resveratrol (usually much less) per five-ounce glass. So you'd have to drink more than 120 bottles of red wine daily to equal one Rez-V™ serving.
- Juan ME et al. Trans-Resveratrol, a natural antioxidant from grapes, Increases sperm output in healthy rats. J Nutr. 2005 Apr;135(4):757-60.
- Bhat KP et al. Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. Cancer Res. 2001 Oct 15;61(20):7456-63.
- Henry LA et al. Resveratrol: phytoestrogen effects on reproductive physiology and behavior in female rats. Horm Behav. 2002 Mar;41(2):220-8.
- Matsumura A et al. Comparative study of oestrogenic properties of eight phytoestrogens in MCF7 human breast cancer cells. J Steroid Biochem Mol Biol. 2005 Apr;94(5):431-43.
- Bowers JL et al. Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta. Endocrinology. 2000 Oct;141(10):3657-67.
- Lu R et al. Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells. J Cell Physiol. 1999 Jun;179(3):297-304.
- Turner RT et al. Is resveratrol an estrogen agonist in growing rats? Endocrinology. 1999 Jan;140(1):50-4.
- Bhat KP et al. Resveratrol exhibits cytostatic and antiestrogenic properties with human endometrial adenocarcinoma (Ishikawa) cells. Cancer Res. 2001 Aug 15;61(16):6137-44.
- Wang Y et al. The Red Wine Polyphenol Resveratrol Displays BI-Level Inhibition on Aromatase in Breast Cancer Cells. Toxicol Sci. 2006 Apr 11
- Wallerath T et al. A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase. Nitric Oxide. 2005 Mar;12(2):97-104.
- Lekakis J et al. Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. Eur J Cardiovasc Prev Rehabil. 2005 Dec;12(6):596-600.
- Buluc M et al. Resveratrol decreases calcium sensitivity of vascular smooth muscle and enhances cytosolic calcium increase in endothelium. Vascul Pharmacol. 2006 Apr;44(4):231-7.
- Labinskyy N et al. Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen. Curr Med Chem. 2006;13(9):989-96.
- Bhat KPL et al. Biological effects of resveratrol. Antioxid Redox Signal. 2001 Dec;3(6):1041-64.
- Bradamante S, et al. Cardiovascular protective effects of resveratrol. Cardiovasc Drug Rev. 2004 Fall;22(3):169-88.
- de la Lastra CA et al. Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol Nutr Food Res. 2005 May;49(5):405-30. doi: 10.1002/mnfr.200500022.
- Delmas D et al. Resveratrol: preventing properties against vascular alterations and ageing. Mol Nutr Food Res. 2005 May;49(5):377-95.
- Valenzano DR et al. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol. 2006 Feb 7;16(3):296-300.
- Marambaud P et al. Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides. J. Biol. Chem 2005 Nov;280(45): 37377-37382
- Molnar V et al. Plant-derived anti-inflammatory compounds affect MIF tautomerase activity. Int Immunopharmacol. 2005 May;5(5):849-56.
- Elmali N et al. Effect of resveratrol in experimental osteoarthritis in rabbits. Inflamm Res. 2005 Apr;54(4):158-62.
- Kopp P. Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'? Eur J Endocrinol. 1998 Jun;138(6):619-20.
- Constant J. Alcohol, ischemic heart disease, and the French paradox. Coron. Artery Dis. 1997; 8:645 – 649.
- Das D K et al. Cardioprotection of red wine: role of polyphenolic antioxidants. Drugs Exp Clin Res. 1999;25(2-3):115-20.
- Soleas GJ, Diamandis EP, Goldberg DM. The world of resveratrol. Adv Exp Med Biol. 2001;492:159-82.
- Wyke SM, Tisdale MJ. Induction of protein degradation in skeletal muscle by a phorbol ester involves upregulation of the ubiquitin-proteasome proteolytic pathway. 2006 May;78(25):2898-2910
- Tisdale MJ. The ubiquitin-proteasome pathway as a therapeutic target for muscle wasting. J Support Oncol. 2005 May-Jun;3(3):209-17.
- Wyke SM et al. Induction of proteasome expression in skeletal muscle is attenuated by inhibitors of NF-kappaB activation. Br J Cancer. 2004 Nov 1;91(9):1742-50.
- Borra MT et al. Mechanism of human SIRT1 activation by resveratrol. J Biol Chem. 2005 Apr 29;280(17):17187-95.
- Picard F, et al. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature. 2004 Jun 17;429(6993):771-6.
- Wolf G. Calorie restriction increases life span: a molecular mechanism. Nutr Rev. 2006 Feb;64(2 Pt 1):89-92.
- Ingram DK et al. Calorie restriction mimetics: an emerging research field. Aging Cell. 2006 Apr;5(2):97-108.
- Roth GS et al. Caloric restriction mimetics: the next phase. Ann N Y Acad Sci. 2005 Dec;1057:365-71.
- Tian WX. Inhibition of fatty acid synthase by polyphenols. Curr Med Chem. 2006;13(8):967-77.
- Kasdallah-Grissa A, et al. Protective effect of resveratrol on ethanol-induced lipid peroxidation in rats. Alcohol Alcohol. 2006 May-Jun;41(3):236-9
- Sener G et al. Protective effects of resveratrol against acetaminophen-induced toxicity in mice. Hepatol Res. 2006 Apr 1; E-Published Ahead of Print
- Docherty JJ et al. Effect of resveratrol on herpes simplex virus vaginal infection in the mouse. Antiviral Res. 2005 Sep;67(3):155-62.
- Jung HJ et al. Fungicidal effect of resveratrol on human infectious fungi. Arch Pharm Res. 2005 May;28(5):557-60.
- Palamara AT et al. Inhibition of influenza A virus replication by resveratrol. J Infect Dis. 2005 May 15;191(10):1719-29.
- Yoo KM et al. Potent Inhibitory Effects of Resveratrol Derivatives on Progression of Prostate Cancer Cells. Arch Pharm (Weinheim). 2006 Apr 18;339(5):238-241
- Jones SB et al. Resveratrol-induced gene expression profiles in human prostate cancer cells. Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):596-604.
- Scifo C et al. Resveratrol and propolis as necrosis or apoptosis inducers in human prostate carcinoma cells. Oncol Res. 2004;14(9):415-26.
- Kim YA et al. Antiproliferative effect of resveratrol in human prostate carcinoma cells. J Med Food. 2003 Winter;6(4):273-80.
- Stewart JR et al. Resveratrol: a candidate nutritional substance for prostate cancer prevention. J Nutr. 2003 Jul;133(7 Suppl):2440S-2443S.
- Ratan HL et al. Resveratrol – a prostate cancer chemopreventive agent? Urol Oncol. 2002 Nov-Dec;7(6):223-7.
- Aggarwal BB, et al. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 2004 Sep-Oct;24(5A):2783-840.
- Aziz MH et al. Cancer chemoprevention by resveratrol: in vitro and in vivo studies and the underlying mechanisms (review). Int J Oncol. 2003 Jul;23(1):17-28.
- Delmas D et al. Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer. Curr Drug Targets. 2006 Apr;7(4):423-42.