There's great interest in safe and natural substances that strengthen the innate immune system. The term for this effect is "trained immunity." Biotest used trained immunity as its design goal when developing the I-Well™ formula by including four potent compounds proven to fortify immunity: beta-1,3-glucan, lipidized turmeric curcumin, EGCG, and microencapsulated Vitamin D3.*
For Trained Immunity*
- Beta-1,3-glucan primes, strengthens, and maintains healthy immunity.
- Solid lipid curcumin particles promote a healthy inflammatory response, neurological health, and cardiovascular health.
- Vitamin D3 supplies a required micronutrient for optimal inflammatory response.
- EGCG supports cellular, cardiovascular, brain, and metabolic health.
Beta-1,3-glucan — A Very Big Deal
Primes, strengthens, and maintains healthy immunity.
Beta-1,3-glucan is a non-digestible polysaccharide isolated from Euglena gracilis algae. It's well established that beta-1,3-glucan acts as an immunomodulatory agent.
This means the body's pattern-recognition receptors (PPRs; Dectin-1) identify beta-1,3-glucan as "non-self" or foreign, which activates healthy immune responses. Triggering these responses with beta-1,3-glucan can prime, strengthen, and support sustained healthy immune function (1-17).
Beta-1,3-glucan also fuels the growth of good bacteria (lactobacillus and bifidobacteria) in the gut, and supports the health of intestinal cells that act as a protective physical barrier (15, 16).
There's nothing else like it. Beta-1,3-glucan is a breakthrough for anyone wanting to maintain a strong, healthy immune system — it's a very big deal.
Curcumin's Great Potential Realized
Promotes a healthy inflammatory response, and supports neurological and cardiovascular health.
Medical researchers have had a longtime interest in curcumin for its positive effects on inflammatory response, neurological health, and cardiovascular health.
But the frustrating problem has always been its poor bioavailability. Curcumin isn't soluble in the gastrointestinal tract, making it difficult to absorb, and it's vulnerable to something called glucuronidation, which converts curcumin into what amounts to inactive waste.
An example of curcumin's poor bioavailability is a study where patients were given a whopping 3.6 grams of ordinary curcumin a day (about 7 capsules). Even at those large doses, detectable blood and liver levels of free-form curcumin were almost non-existent (18).
Absorb 95X More Curcumin*
There is a solution for optimal curcumin uptake. Research shows solid lipid curcumin particles produce 95 times more free curcumin in the bloodstream than highly pure, standardized curcumin (Gota VS et al, 2010).*
That's a bold claim. Fortunately, solid lipid curcumin particles are backed up with convincing science, invented by neuroscientists at UCLA, funded by the University of California (Oakland) and the Federal Government, supported by peer-reviewed research on humans, and patented (9,192,644).
Microencapsulated Vitamin D3
Supplies a required micronutrient for optimal inflammatory response.
Research shows Vitamin D3 (choleocalciferol) is a required micronutrient for maintaining an optimal inflammatory response and healthy immune system (40-44).
Unfortunately, vitamin D deficiencies are rampant, especially in the areas with the least exposure to the sun. That's because the body naturally produces Vitamin D when skin has direct exposure to sunlight. Adding to the problem, it's difficult to absorb enough D3 in our diets.
Without proper or optimal vitamin D levels, T cells aren't effective and flat out don't activate (40). To make matters worse, it's really difficult to achieve or maintain adequate levels of D3 with most supplementation (45).
The I-Well™ formula contains microencapsulated vitamin D3, which presents as tiny, water dispersible "beadlets" that enhance uptake.
Studies show that this microencapsulated form is the most bioavailable and longest lasting. Its effects remain constant for up to 14 days, making it clearly superior to the oil-based vitamin D3 supplements that make up most of the market (45).
Supports cardiovascular, brain, metabolic, and cellular health.
EGCG (epigallocatechin-3-gallate) is a powerful health-promoting polyphenol found in green tea — having positive effects on the body's inflammation response and on various target tissues (46-54).
A host of studies (mostly in vitro) show EGCG has protective effects on the cardiovascular (47, 48) and nervous systems (47, 52-54). It promotes cellular health (50, 52), and stimulates metabolic function (48, 49).
Amount Per Serving % Daily Value
Other Ingredients: Rice flour, hypromellose (vegetable capsule), rice hull concentrate, L-leucine.
- Take three capsules once per day with food, preferably the largest meal of the day.
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- Carlos AF et al. β-Glucan successfully stimulated the immune system in different jawed vertebrate species. Comparative Immunology, Microbiology and Infectious Diseases, Volume 62, February 2019, Pages 1-6.
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- Gota VS et al. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. J Agric Food Chem. 2010 Feb 24;58(4):2095-9. DOI: 10.1021/jf9024807.
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- [Lipidated curcumin] binds to amyloid in human CNS after a single dose. Unpublished.
- A phase 1 open-label prospective cohort trial of curcumin plus tyrosin kinase inhibitors for EGFR-mutant advanced NSCLC. McGill U & Jewish General Hospital, Canada. Ongoing.
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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Disclaimer: Individual results may vary.