- Activates muscle growth for greater training gains.*
- 50% greater increase in muscle cross-sectional area and lean body mass*
- 40% greater increase in total strength (upper and lower body)*
- 60% greater loss in body fat*
Amplified Results From Lifting Weights
Micro-PA is not one of those supplements that promises more muscle and less fat without any effort. No, Micro-PA is a supplement for people who are already working hard in the gym.
It's a supplement for people who simply want better, faster results from the hard work they're already doing. They don't want "easy," but they do want their progress to be amplified and accelerated.
Micro-PA has been proven in multiple, smartly designed scientific studies to do just that. And these studies weren't conducted on beginners. They were done on experienced lifters and athletes. Compared to test subjects receiving a placebo and doing the exact same workout program, PA users experienced:*
- 50% greater increase in muscle mass(1)*
- 40% greater increase in total strength(1)*
- 60% greater loss in body fat(2)*
(1)Hoffman et al 2012
(2)Wilson et al 2014
The New Science of Hypertrophy
Micro-PA contains a highly specialized form of unsaturated phosphatidic acid (PA), with enhanced bioavailability, that powerfully activates and amplifies muscle cell protein synthesis.*
Here's how it works. Your body makes an enzyme that regulates the growth of muscle. This kinase enzyme is called mTOR, and it's the "master regulator" of muscle cell protein synthesis and muscle size.*
When you're lifting weights, an enzyme is dislodged from muscle cells that hydrolyzes phosphatidylcholine into PA. This happens primarily in the eccentric or negative phase of weight training, like when you lower a barbell curl under control. PA then binds to and activates mTOR.* PA-activated mTOR directly affects immediate and long-term changes in muscle growth.*
Simply put, if you want to gain muscle, you have to activate mTOR.* And the more PA available to activate mTOR, the greater the effect on intracellular protein synthesis and the greater the muscle mass gains.*
If you take additional PA in the form of a supplement, you activate more mTOR.* Basically, you can do a workout and get "X" gains from that workout. Or you can take Micro-PA and get "XX" gains from the very same workout.*
You're still working hard, you're just getting a much greater payoff from your hard work: more muscle, more strength, more fat loss.*
Orally Bioavailable PA
PA is a phospholipid that contains two fatty acids and a phosphate group. Eggs naturally contain PA but the fatty acids are saturated. That means the PA gets incorporated into the cell membrane.*
To make supplemental PA work directly, it must enter into the muscle cell and bind to MTOR.* In can also work indirectly by converting to lyso-phosphatidic acid and attaching to the muscle cell membrane, which increases intracellular PA and in turn activates mTOR.*
To achieve this, the PA must be unsaturated.* Chemi Nutra, one of the industry's most innovative materials manufacturers, has been able to produce an unsaturated, orally bioavailable form of PA that activates mTOR — an 8-fold increase activation of mTOR! Bioavailability of PA significantly rises in 30 minutes after dosing and stays elevated for 7 hours.*
Chemi Nutra's phosphatidic acid, along with Biotest's self-microemulsifying nutrient deliver system, is what you'll find in Micro-PA.
- A study, involving resistance trained men undergoing a very intense exercise program, showed subjects supplementing with 750 mg PA per day achieved 50% greater increase in muscle cross-sectional area and lean body mass, 40% greater increase in total strength (upper and lower body), and 60% greater loss in body fat than the training-only group (Wilson et al 2014).*
- Another study, involving resistance trained men undergoing an 8-week exercise program, showed subjects taking 750 mg of PA per day gained significantly more lean body mass and strength than the training-only group (Hoffman et al. 2013).*
- Yet another study recruited 18 lifters and split them into two groups. One half received a daily dose of a formulation that contained 750 mg of phosphatidic acid and the other half received a placebo. All followed the same training program three days a week for 8 weeks and followed the identical diet. Those taking the supplement with phosphatidic acid gained more muscle and power, lost more fat, and gained more than twice the strength as the placebo group (Escalante, et al 2016).*
How to Use Micro-PA
For best results, take 750 mg of Micro-PA an hour before training. Micro-PA can also be used on non-training days as it activates brown adipose tissue (BAT), leading to greater fat loss.*
Micro-PA can be used by men and women. Phosphatidic acid is not on the banned substance list of any known athletic or bodybuilding organization and will not lead to failed drug tests.
"Even after cutting I was 8 pounds heavier!"
I used Micro-PA in a 12 week cycle and I saw greater strength and muscle gains. Even after cutting I was 8 pounds heavier than before I started using Micro-PA!
"The effects of Micro-PA are very noticeable."
With Micro-PA I achieved impressive gains in strength in size. The effects of are very noticeable.
"Strength gains are significant with Micro-PA."
I'm a competitive female powerlifter and figure competitor. Recently, I've been using Micro-PA while dieting for an upcoming powerlifting competition. Normally my goal is to reach my target weight without losing strength. But instead of maintaing strength, with Micro-PA I've gained strength and actually hit PR's in all the lifts.
"I notice a long-lasting thermic effect."
The most attributable 'feeling' I get from Micro-PA is body heat. When taking it pre-workout, I feel hotter and more thermic that extends for a long period of time after training. I approached Micro-PA for the hypertrophy effect, but I think the process of ramping up protein synthesis will favorably impact body composition as well!
"I packed on 5 more pounds of muscle!"
Previously it had taken me 4-5 years to add 10 pound of stage weight to my body, and that's a pretty good rate of gain for a competitive bodybuilder.
Four weeks ago, I started taking Micro-PA, and the results are pretty amazing. In spite of the fact I was sick one of those weeks and had to literally train dragging an oxygen tank around and tubes in my nostrils, I managed to pack on 5 more pounds of muscle!
So do I believe Micro-PA made the difference? Are you crazy? Absolutely yes!
1. Gundermann, D et al. Soy-derived Phosphatidic Acid, Lysophosphatidic Acid and Phosphatidylserine are Sufficient to Induce an Increase in mTOR Signaling. Poster presented at the 2013 annual ISSN conference, and manuscript now in review for submission to publication.
2. Hoffman, JR et al. Efficacy of phosphatidic acid ingestion on lean body mass, muscle thickness and strength gains in resistance-trained men. Journal of the International Society of Sports Nutrition. 9:47 2012.
3. Joy, JM et al. Phosphatidic Acid Supplementation Increases Skeletal Muscle Hypertrophy and Strength. Poster presented at the 2013 annual ISSN conference, and manuscript now in review for submission to publication.
4. Joy, JM et al. The Effects of 8 Weeks of Phosphatidic Acid Supplementation on Cardiovascular, Kidney, and Liver Safety in Health Young Males. Poster presented at the 2013 annual ISSN conference.
5. Purpura M et al. Effect of Oral Administration of Soy-Derived Phosphatidic Acid on Concentrations of Phosphatidic Acid and lyso-Phosphatidic Acid Molecular Species In Human Plasma. Poster presented at the 2013 annual ISSN conference.
6. Adegoke, OA, Abdullahi, A, Tavajohi-Fini, P. mTORC1 and the regulation of skeletal muscle anabolism and mass. Applied Physiology, Nutrition, and Metabolism. Vol. 37, No. 3: 395-406, 2012.
7. Donati C, et al. New insights into the role of sphingosine 1-phosphate and lysophosphatidic acid in the regulation of skeletal muscle cell biology. Biochimica et Biophysica Acta, 2012, http://dx.doi.org/10.1016/j.bbalip.2012.06.013.
8. Foster, D et al. Phosphatidic acid and lipid-sensing by mTOR. Cell Press Articles In Press, Trends in Endocrinology and METABOLISM XX (2012) 1-7.
9. Harrington, LS, Findlay, GM, and Lamb, RF. Restraining PI3K: mTOR signaling goes back to the membrane. TRENDS in Biochem Sci 30(1): 35-42, 2005.
10. Hornberger, TA, Chu, WK, Mak, YW, Hsiung, JW, Huang, SA, and Chien, S. The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle. PNAS 103(12): 4741-4746, 2006.
11. Hornberger, TA, Sukhija, KB, Chien, S. Regulation of mTOR by mechanically induced signaling events in skeletal muscle. Cell Cycle 5(13): 1391-1396, 2006.
12. Hulmi JJ et al. Resistance exercise with whey protein ingestion affects mTOR signaling pathway and myostatin in men. J Appl Physiol 106: 1720-1729, 2009.
13. Laplante M et al. An emerging Role of mTOR in Lipid Biosynthesis. Current Biology 19, R1046-R1052, Dec 1, 2009. Elsevier Ltd.
14. Lehman, N, Ledford, B, Di Fulvio, M, Frondorf, K, McPhail, LC, and Gomez-Cambronero, J. Phospholipase D2-derived phosphatidic acid binds to and activates ribosomal p70 S6 kinase independently of mTOR. FASEB J 21: 1075-1087, 2007.
15. O’Neil, TK, Duffy, LR, Frey, JW, and Hornberger, TA. The role of phosphoinositide 3-kinase and phosphatidic acid in the regulation of mammalian target of rapamycin following eccentric contractions. J Physiol 581.14: 3691-3701, 2009.
16. Rasmussen, BB. Phosphatidic acid: a novel mechanical mechanism for how resistance exercise activates mTORC1 signaling. J Physiol 587.14: 3415-3416, 2009.
17. Sengupta, S, Peterson, TR, and Sabatini, DM. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Molecular Cell 40: 310-322, 2010.
18. Stipp D. A New Path To Longevity. Scientific American, January 2012.
19. Veverka, V, Crabbe, T, Bird, I, Lennie, G, Muskett, FW, Taylor, RJ, and Carr, MD. Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: Compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR. Oncogene 27: 585-595, 2008.
20. Vissing K et al. Differentiated mTOR but not AMPK signaling after strength vs endurance exercise in training-accustomed individuals. Scand J Med Sci Sports, 2011, doi 10.1111/j.1600-0838.2011.01395.x.
21. Walker, DK, Dickinson, JM, Timmerman, KL, Drummond, MJ, Reidy, PT, Fry, CS, Gundermann, DM, and Rasmussen, BB. Exercise, amino acids, and aging in the control of human muscle protein synthesis. J Am Coll Sport Med 43(12): 2249-2258, 2011.
22. Winter, JN, Fox, TE, Kester, M, Jefferson, LS, and Kimball, SR. Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway. Am J Physiol Cell Physiol 299: C335-C344, 2010.
23. Xu, Y, Fang, Y, Chen, J, and Prestwich, GD. Activation of mTOR signaling by novel fluoromethylene phosphonate analogues of phosphatidic acid. Bio Med Chem Letter 14: 1461-1464, 2004.
24. Yamada, AK, Verlengia, R, Bueno, CR. Mechanotransduction pathways in skeletal muscle hypertrophy. Journal of Receptors and Signal Transduction 2011.
25. Zanchi, NE, and Lancha, AH Jr. Mechanical stimuli of skeletal muscle: Implications on mTOR/p70s6k and protein synthesis. Eur J Appl Physiol 102: 253-263, 2008.
26. Zhang C et al. Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling. PNAS Early Edition, www.pnas.org/content/early/2012/01/10/1110730109.full.pdf.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Disclaimer: Individual results may vary.