P-Well™

Prostate Support*

• Promotes healthy prostate size and function
• Helps manage oxidative stress and inflammation
• Supports healthy urination and bladder emptying
• Helps protect prostate cells
• Promotes healthy hormone metabolism in the prostate
• Helps maintain already healthy PSA levels

Sexual Vascular Health*

• Promotes better blood flow to the penis
• Helps improve sperm quality and motility

Urinary Tract Health*

• Supports healthy urinary flow
• Helps protect urinary tract surface and lining

Despite its playful name, the P-Well™ formula is based on serious science. Instead of using every potential ingredient that might have a positive effect, Biotest chose to include only the heavy hitters of prostate health, sexual function, and urinary tract health:

Punicalagins from pomegranate whole fruit extract

Punicalagins are tannins found in pomegranate and pomegranate juice. You might not have heard of them before, but punicalagins and their metabolites, ellagic acid and urolithins, are largely responsible for pomegranate's reputation of being a super-healthy fruit with almost unparalleled qualities. While it's an incredibly potent antioxidant, about three times greater than green tea or red wine, pomegranate directly benefits the male reproductive system in these powerful ways:*

• Helps manage reproductive inflammation
• Promotes healthy prostate size and function
• Supports healthy hormone metabolism in the prostate
• Helps maintains already healthy PSA levels
• Promotes better blood flow to the penis
• Supports healthy urinary flow

Lycopene from natural tomato fruit extract

Lycopene is a red carotenoid pigment that gives tomatoes, watermelons, and pink grapefruit their characteristic color. Lycopene has over 2,000 peer-reviewed studies dedicated to it, making it one of the most studied plant chemicals ever. Even though its health-promoting effects are diverse, lycopene specifically fortifies male reproductive health in the following unique ways:*

• Helps protect prostate cells from oxidative stress*
• Promotes improved sperm quality and motility*

Cranberry whole fruit 50:1 concentrate

Cranberries contain a variety of plant chemicals with positive effects on the urinary tract. This is especially true with a strong cranberry concentrate like that found in the P-Well™ formula. Multiple studies show cranberry, especially cranberry concentrate, sustains the health of the muscles that control the bladder and provides the following important advantages for the urinary tract:*

• Promotes healthy urination and bladder emptying
• Helps protect urinary tract surface and lining

SUPPLEMENT FACTS

Servings Size 3 Capsules
Servings Per Container 30

Amount Per Serving % Daily Value

Punicalagins (from pomegranate whole fruit extract) 180 mg†

Lycopene (from natural tomato fruit extract) 30 mg†

Cranberry whole fruit 50:1 concentrate 500 mg†

† Daily Value not established.

Other Ingredients: Rice flour, hypromellose (vegetable capsule), rice hull concentrate, L-leucine.

• Take three capsules once per day with food.
• Drink at least eight ounces of water per dose.

Pomegranate References

1. Sharma P et al. Pomegranate for Prevention and Treatment of Cancer: An Update. Molecules. 24 January 2017.
2. Vicinanza R et al. Pomegranate Juice Metabolites, Ellagic Acid and Urolithin A, Synergistically Inhibit Androgen-Independent Prostate Cancer Cell Growth via Distinct Effects on Cell Cycle Control and Apoptosis. Evidence Based Complementary and Alternative Medicine. 19 February 2013.
3. Wang L et al. Cellular and molecular mechanisms of pomegranate juice-induced anti-metastatic effect on prostate cancer cells. Integr Biol. 2011 May 19.
4. Chaves FM et al. Pomegranate Juice and Peel Extracts are Able to Inhibit Proliferation, Migration and Colony Formation of Prostate Cancer Cell Lines and Modulate the Akt/mTOR/S6K Signaling Pathway. Plant Foods Hum Nutr. 2020 March;75(1):54-62.
5. Kroeger N et al. Pomegranate Extracts in the Management of Men's Urologic Health: Scientific Rationale and Preclinical and Clinical Data. Evid Based Complement Alternat Med. 2013 Mar 26.
6. Forest CP et al. Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, crossover study. Int J Impot Res. Nov-Dec 2007;19(6):564-7.
7. Jeranka JS. Therapeutic Applications of Pomegranate (Punica granatum L.): A Review. Alternative Medicine Review: A Journal of Clinical Therapeutic, July 2008,13(2):128-44.
8. Gur S et al. Characterisation of pomegranate juice effects on human corpus cavernosum. Andrologia 2017 Oct;49(8).
9. Azadzoi K et al. Oxidative stress in arteriogenic erectile dysfunction: prophylactic role of antioxidants. J Urol. 2005 Jul;174(1):368-93.
10. Deng Y et al. The extract from Punica granatum (pomegranate) peel induces apoptosis and impairs metastasis in prostate cancer cells. Biomed Pharmacother. 2017 Se9;93:976-984.
11. Bassiri-Jahromi S. Punica granatum (Pomegranate) activity in health promotion and cancer prevention. Oncol Res. 2018 Jan 30;12(1):345.
12. Chrubasik-Hausman S et al. Pomegranate juice and prostate cancer: importance of the characterisation of the active principle. Phytoter Res. 2014 Nov;28(11):1676-8.
13. Wang L et al. Pomegranate and Its Components as Alternative Treatment for Prostate Cancer Int J Mol Sci. 2014 Sep; 15 (9):14949-14966.
14. Amri Z et al. Growth Inhibitory and Pro-Apoptotic Effects of Ornamental Pomegranate Extracts in Du145 Human Prostate Cancer Cells. Nutrition and Cancer. Volume 72. 2020. Issue 6.

Lycopene References

15. Chen P et al. Lycopene and Risk of Prostate Cancer. A Systematic Review and Meta-Analysis. Medicine (Baltimore). 2015 Aug;94(33): 31260.
16. Lane JA et al. ProDiet: A Phase II Randomized Placebo-controlled Trial of Green Tea Catechins and Lycopene in Men at Increased Risk of Prostate Cancer. Cancer Pres Res. 2018 Nov;11(1): 687-696.
17. Wang Y et al. Lycopene, tomato products and prostate cancer-specific mortality among men diagnosed with nonmetastatic prostate cancer in the Cancer Prevention Study II Nutrition Cohort. Int J Cancer. 2016 June 15;138 (12):2846-55.

Cranberry References

18. Vidlar A et al. The effectiveness of dried cranberries ( Vaccinium macrocarpon) in men with lower urinary tract symptoms. Brit J Nutr, 2010 Oct;104(8):118-9.
19. Wang CH et al. Cranberry-Containing Products for Prevention of Urinary Tract Infections in Susceptible Populations: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Arch Intern Med. 2012;172(13):988-996.
20. Luis A et al. Can Cranberries Contribute to Reduce the Incidence of Urinary Tract Infections? A Systematic Review with Meta-Analysis and Trial Sequential Analysis of Clinical Trials. The Journal of Urology. Volume 3 198. Issue 3. September 2017. Pages 614-621.