Nothing hinders mental and physical well-being more than lack of sleep. It's a huge problem; research confirms at least 33% of adults have chronic insomnia. Regardless of the cause, inadequate sleep takes its toll on life, health, and vitality. Enter Biotest's Z-12™ formula for a full night's sleep without the "hangover" associated with virtually all sleep aids. Just take two capsules at bedtime, and typically you'll fall into a deep, restful, uninterrupted sleep within 15 minutes and wake up the following morning entirely refreshed and ready to go.*
Who benefits from Z-12™ capsules?
- People worried about tomorrow's exam, job interview, or athletic competition*
- Travelers trying to overcome first-night restlessness in a new time zone or bed*
- People who regularly have trouble falling asleep*
- People who wake in the middle of the night and can't go back to sleep*
The main workhorse in Z-12 is phGABA, a derivative of the inhibitory neurotransmitter GABA. When we're stressed, our brains experience an uninterrupted flow of stimulatory neurotransmitters, causing restlessness and irritability.*
GABA, and phGABA in Biotest's Z-12, inhibit the flow of these stimulatory neurotransmitters, thereby calming the brain and body. PhGABA not only acts like GABA, but it also causes the release of GABA for a one-two sleep-inducing punch.*
Double-blind studies find phGABA increases intellectual function, improves physical strength and reduces fatigue in stressed individuals. It improves work capacity in humans and the performance of animals during swim tests. PhGABA also has cardioprotective properties. The plasma half-life of PhGABA (250 mg) is 5.3 hours, with most of it excreted unchanged.*
5-HTP (5-hydroxytryptophan) is a naturally occurring amino acid and precursor to the neurotransmitter serotonin (5-hydroxytryptamine). Boosted 5-HTP causes the brain's serotonin-producing neurons to increase production, facilitating sleep and elevating feelings of well-being.*
Furthermore, there's evidence that 5-HTP actually "resets" (normalizes) the hypothalamic-pituitary-adrenal (HPA) axis. In addition to helping the body adapt better to stress, this resetting effect also helps PhGABA and L-theanine continue working.*
L-Theanine is an amino acid found in green tea. Due to it promoting brain alpha-wave function, L-theanine facilitates a calm, relaxed mental state. Animal studies suggest it increases brain serotonin and GABA levels, along with being neuroprotective and cognitive enhancing.*
- Take 2-4 capsules on an empty stomach 30 minutes prior to bedtime, or whenever desiring a calm, relaxed state.
- To determine the ideal dose, begin with two capsules per day and increase by one capsule per day (up to a maximum of four) until achieving the desired effect.
- Never exceed four capsules per day.
- To keep the body sensitive to the effects, do not take more than once per day.
- Bhaskar S et al. Prevalence of chronic insomnia in adult patients and its correlation with medical comorbidities. J Family Med Prim Care. Oct-Dec 2016;5(4):780-784. doi: 10.4103/2249-4863.201153. ABSTRACT: Introduction: Insomnia is one of the common but neglected conditions seen in family practice with long term and serious effects on health of a patient. Family physicians have the responsibility of diagnosing and adequately treating this. This study was done to find the prevalence of chronic insomnia in adult patients visiting a family medicine outpatient department (OPD) in a hospital and to assess the risk factors and co morbidities associated with it. Materials and methods: A cross-sectional study was done in the family medicine OPD at St. Philomena's Hospital, Bengaluru. All adult patients attending the OPD from September 1 to October 30, 2015 were enrolled in the study after obtaining written consent. Athens Insomnia Scale was used to diagnose insomnia and information regarding medical co morbidities was collected. Data was analyzed for the prevalence of insomnia and its association with co morbidities. Results: Chronic insomnia was seen in 33% of the adult population sampled. Increasing age and diabetes were significantly associated with insomnia, while other socioeconomic factors and co morbidities were not significantly associated. Twenty-seven percent of patients who had insomnia did not perceive the condition, which was statistically significant. Conclusion: Insomnia is a common sleep disorder which is many times missed by a primary care physician until/unless asked for. Since there is a higher incidence with increasing age and co morbidities such as diabetes, all patients, especially middle-aged and diabetics, should be screened for insomnia by the primary care physician with a self assessed questionnaire and counseled.
- Park SK et al. A combination of green tea extract and L-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind placebo-controlled study. J Med Food. 2011 Apr;14(4):334-43.
- Giesbrecht T et al. The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutr Neurosci. 2010 Dec;13(6):283-90.
- Einšther SJ et al. L-theanine and caffeine improve task switching but not intersensory attention or subjective alertness. Appetite. 2010 Apr;54(2):406-9.
- Kim TI et al. L-Theanine, an amino acid in green tea, attenuates beta-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-kappaB pathways. Free Radic Biol Med. 2009 Dec 1;47(11):1601-10. Epub 2009 Sep 16.
- Gomez-Ramirez M et al. The effects of L-theanine on alpha-band oscillatory brain activity during a visuo-spatial attention task. Brain Topogr. 2009 Jun;22(1):44-51.
- Owen GN et al. The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutr Neurosci. 2008 Aug;11(4):193-8.
- Nobre AC et al. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr. 2008;17 Suppl 1: 167-8.
- Bryan J et al. Psychological effects of dietary components of tea: caffeine and L-theanine. Nutr Rev. 2008 Feb;66(2):82-90.
- Haskell CF et al. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol Psychol. 2008 Feb;77(2):113-22.
- Nathan PJ et al. The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. J Herb Pharmacother. 2006;6(2):21-30.
- Kimura K et al. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007 Jan;74(1):39-45.
- Lapin I. Phenibut: a tranquilizer and nootropic drug. CNS Drug Rev. 2001 Winter;7(4):471-81.
- Blackshaw LA. Receptors and transmission in the brain-gut axis: potential for novel therapies. IV. GABA(B) receptors in the brain-esophageal axis. Am J Physiol Gastrointest Liver Physiol. 2001 Aug;281(2):G311-5.
- Lapin IP. Differences and similarity in the interaction of fenibut, baclofen, and diazepam with phenylethylamine. Farmakol Toksikol. 1985 Jul-Aug;48(4).
- Shulgina GI. On neurotransmitter mechanisms of reinforcement and internal inhibition. Pavlov J Biol Sci. Oct-Dec 1986;21(4):129-40. doi: 10.1007/BF02734511.
- Maes M et al. Effects of serotonin precursors on the negative feedback effects of glucocorticoids on hypothalamic-pituitary-adrenal axis function in depression. Psychoneuroendocrinology. 1995;20(2):149-67. doi: 10.1016/0306-4530(94)00049-g.
- Birdsall TC. 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Altern Med Rev. 1998 Aug;3(4):271-80.
- Maffei ME. 5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology. Int J Mol Sci. 2020 Dec 26;22(1):181. doi: 10.3390/ijms22010181.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Disclaimer: Individual results may vary.