Turmeric curcumin is arguably the most effective natural inflammation fighter and heart-health supplement. Biotest's Micellar Curcumin™ formula contains solid lipid curcumin particles that produce 95 times more free curcumin in the bloodstream than highly pure, standardized curcumin with piperine (Gota VS et al, 2010).* The formula's solid lipid curcumin particles are backed up with convincing science, invented by neuroscientists at UCLA, funded by the University of California (Oakland) and the Federal Government, and supported by peer-reviewed research on humans patented (9,192,644).*
- Delivers 95 times more active curcumin into the bloodstream than piperine formulas*
- Promotes a healthy inflammatory response*
- Supports cardiovascular health*
- Protects brain and neurological health*
- Supports healthy carbohydrate metabolism*
Absorb 95X More Curcumin*
Medical researchers have had a longtime interest in curcumin for its positive effects on inflammatory response, neurological health, and cardiovascular health. But the frustrating problem has always been its poor bioavailability. Curcumin isn't soluble in the gastrointestinal tract, making it difficult to absorb, and it's vulnerable to something called glucuronidation, which converts curcumin into what amounts to inactive waste.
An example of curcumin's poor bioavailability is a study where patients were given a whopping 3.6 grams of ordinary curcumin a day (about 7 capsules). Even at those large doses, detectable blood and liver levels of free-form curcumin were almost non-existent (18).
There is a solution for optimal curcumin uptake. Research shows solid lipid curcumin particles produce 95 times more free curcumin in the bloodstream than highly pure, standardized curcumin (Gota VS et al, 2010).*
A Better Curcumin: Solid Lipid Curcumin Particles
There are two significant hurdles in making curcumin effective:
- Getting enough of the active compound absorbed into the bloodstream.*
- Protecting it from being deactivated from glucuronidation.*
After 10 years of research, development, and endless tweaking, neuroscientists at UCLA figured produced what they call Solid Lipid Curcumin Particle Technology. This technology is what Biotest uses in its Micellar Curcumin™ supplement.
In simplest terms, the process involves coating curcumin with lipids to form protective micelles then drying the mixture into solid lipid particles. Once in the stomach, the curcumin micelles are easily absorbed into the bloodstream through the lymphatic system and protected from glucuronidation.
Other Ingredients: Rice flour, hypromellose (vegetable capsule), rice hull concentrate, L-leucine.
- Take one or two capsules once per day with food.
Is the curcumin in Biotest's Micellar Curcumin and I-Well the same special type and dose?
Yes, the Micellar Curcumin™ and I-Well™ supplements both contain solid lipid curcumin particles (lipidized curcumin), the kind with 95 times greater absorption. Both formulas also provide 400 mg of lipidized curcumin per dose. Micellar Curcumin™ comes in a 60 day supply. I-Well provides a 30 day supply but also contains three additional potent immune support compounds: beta-1,3-glucan, microencapsulated Vitamin D3, and EGCG (epigallocatechin-3-gallate).
- Gota VS et al. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. J Agric Food Chem. 2010 Feb 24;58(4):2095-9. doi: 10.1021/jf9024807.
- Cox KHM et al. Further evidence of benefits to mood and working memory from lipidated curcumin in healthy older people: A 12-week, double-blind, placebo-controlled, partial replication study. Nutrients. 2020 Jun 04. 12(6): 1678. doi: 10.3390/nu12061678.
- Esfahani K et al. A phase I open prospective cohort trial of curcumin plus tyrosine kinase inhibitors for EGFR-mutant advanced non-small cell lung. J Clin Oncol. 2019. 37(15_suppl): e20611-e20611. doi: 10.1200/JCO.2019.37.15_suppl.e20611.
- Scholey A et al. Curcumin improves hippocampal function in healthy older adults: A three month randomized controlled trial. Poster Presentation in: 13th European Nutrition Conference - Malnutrition in an Obese World: European Perspectives (FENS). Dublin, Ireland. 2019: P3-01-02.
- Scholey A et al. A highly bioavailable curcumin extract improves neurocognitive function and mood in healthy older people: A 12-week randomized, double-blind, placebo-controlled trial (OR32-05-19). Current Dev Nut. 2019 Jun. Poster Presentation. Volume 3(Issue Supplement 1): nzz052.OR32–05–19. doi: 10.1093/cdn/nzz052.OR32-05-19.
- Gupte PA et al. Evaluation of the efficacy and safety of capsule solid lipid curcumin particles in knee: A pilot clinical study. J Inflamm Res. 2019. 12: 145-152. doi: 10.2147/JIR.S205390.
- Koronyo, Y et al. Retinal amyloid pathology and proof-of-concept imaging trial. JCI Insight. 2017. 2(16). doi: 10.1172/jci.insight.93621.
- Santos-Parker JR et al. Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailiability and reducing oxidative stress. Aging. 2017 Jan. 3. Vol 9(No1): 187-208.
- McFarlin et al. Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin. University of North Texas. BBA Clinical. 2016 Feb 18. 5: 72-78. doi: 10.1016/j.bbacli.2016.02.003.
- Santos-Parker JR et al. Curcumin supplement improves vascular endothelial function in middle-aged and older adults. Geront. 2015 Dec. 55(Suppl 2): 195. doi: 10.1093/geront/gnv554.01.
- Rafii MS et al. The biomarker initiative DSBI pilot: Proof of concept for deep phenotyping of biomarkers. Front Behav Neurosci. 2015. 9: 1-11.
- Cox KH et al. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. Centre for Human Psychopharmacology, Swinburne University. J Psychopharmacol. 2015 May. Vol 29(No 5): 642-651. doi: 10.1177/0269881114552744.
- Hazarey VK et al. Efficacy of curcumin in the treatment for oral health – A randomized clinical trial. Government Dental College and Hospital. Nagpur, Maharashtra, India. J Oral Maxillofac Pathol. 2015. 19: 145-52. doi: 10.4103/0973-029X.164524.
- Machida N et al. Effects of Solid, Lipid Curcumin Particles on alcohol metabolism - An expiatory and a randomized, double-blind, placebo-controlled, parallel-group crossover study. Jpn Pharmacol Ther. 2020 Apr. 48(5): 867-873.
- Frost S et al. Retinal amyloid fluorescence imaging predicts cerebral amyloid burden. Alz Dement. 2014. 10(4): P234-P235.
- DiSilvestro et al. Diverse effects of a low-dose supplement of lipidated curcumin in healthy middle-aged people. The Ohio State University. Nutr. J. 2012 Sep 26. 11(79). doi: 10.1186/1475-2891-11-79.
- Khattry N et al. Curcumin decreases cytokine levels involved in mucositis in autologous transplant setting: A pharmacokinetic-pharmacodynamic study. Poster presented at 54th American Society of Hematology (ASH) Annul Meeting. Atlanta, GA. 2012 Dec 08. Blood. 120(21): 3039.
- Shah et al. Acute human pharmacokinetics of a lipid-dissolved turmeric extract. Planta Med. 2012. 48-PH5.
- Pharmacokinetics of [lipidated curcumin]: Dose-concentration correlation. Unpublished, UCLA 2011-2012.
- Gota et al. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in patients and healthy volunteers. Tata Memorial Cancer Centre. J Ag Food Chem. 2010. 58(4): 2095-2099.
- [Lipidated curcumin] binds to amyloid in human CNS after a single dose. Unpublished.
- A phase 1 open-label prospective cohort trial of curcumin plus tyrosin kinase inhibitors for EGFR-mutant advanced NSCLC. McGill U & Jewish General Hospital, Canada, Ongoing.
Solid Lipid Curcumin Particles (Lipidized Curcumin)
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Disclaimer: Individual results may vary.